317-622-8970Search all companies →Largest Healthcare & Life Science Companies in Illinois (2026)
Factur's directory lists 175,537 healthcare & life science companies in Illinois. These are the 10 largest of them by annual revenue, led by CommonSpirit Health ($39.1B), McDonald's Corp ($26.9B) and Advocate Aurora Health ($14B).
Size mix: of the 175,530 with a known headcount, 98.8% have 1-50 employees, 1,573 companies 51-200, 453 companies 201-1000, 76 companies 1001-5000 and 43 companies 5001+. 231 employ more than 500 people.
The 10 largest healthcare & life science companies in Illinois by annual revenue
| # | Company | City | Employees | Annual revenue |
|---|---|---|---|---|
| 1 | CommonSpirit Health | Chicago | 160,000 | $39.1B |
| 2 | McDonald's Corp | Chicago | 150,000 | $26.9B |
| 3 | Advocate Aurora Health | Downers Grove | 150,000 | $14B |
| 4 | Northwestern Medicine | Chicago | 38,000 | $9.6B |
| 5 | Hyatt Hotels Corp | Chicago | 242,000 | $7.1B |
| 6 | Option Care Health Inc | Bannockburn | 8,000 | $5.6B |
| 7 | Advocate Health Care | Downers Grove | 35,816 | $5.3B |
| 8 | OSF Healthcare System | Peoria | 23,792 | $4.1B |
| 9 | Select Rehabilitation LLC | Glenview | 21,000 | $3.1B |
| 10 | TAG - The Aspen Group | Chicago | 20,000 | $2.9B |
How this list is ranked
Companies are ranked by annual revenue (USD) as recorded on each company's profile in the Factur directory, highest first; companies with the same revenue are ordered by employee count. Only companies with a positive revenue figure on file are ranked, so a large private company with no reported revenue can be missing. The list covers companies whose record places them in Illinois and whose Factur industry is Healthcare & Life Science. Figures are a snapshot of the directory, refreshed when the rankings are regenerated; open a profile for its current data.