317-622-8970Search all companies →Largest Healthcare & Life Science Companies in South Carolina (2026)
Factur's directory lists 46,472 healthcare & life science companies in South Carolina. These are the 10 largest of them by annual revenue, led by Prisma Health ($6B), Medical University of South Carolina ($3.5B) and Medical University of South Carolina (MUSC) ($3.1B).
Size mix: of the 46,471 with a known headcount, 98.6% have 1-50 employees, 1% 51-200, 130 companies 201-1000, 20 companies 1001-5000 and 8 companies 5001+. 46 employ more than 500 people.
The 10 largest healthcare & life science companies in South Carolina by annual revenue
| # | Company | City | Employees | Annual revenue |
|---|---|---|---|---|
| 1 | Prisma Health | Greenville | 36,698 | $6B |
| 2 | Medical University of South Carolina | Charleston | 31,000 | $3.5B |
| 3 | Medical University of South Carolina (MUSC) | Charleston | 22,300 | $3.1B |
| 4 | HCA South Atlantic | Charleston | 21,000 | $3.1B |
| 5 | Spartanburg Regional Healthcare System | Spartanburg | 10,000 | $1.5B |
| 6 | McLeod Health | Myrtle Beach | 15,000 | $973M |
| 7 | Roper St Francis Healthcare | Charleston | 6,000 | $881M |
| 8 | Greenville Hospital System University Medical Grp | Greenville | 1,059 | $719M |
| 9 | Medical University Hospital Authority | Mullins | 1,092 | $612M |
| 10 | AnMed | Anderson | 3,600 | $528M |
How this list is ranked
Companies are ranked by annual revenue (USD) as recorded on each company's profile in the Factur directory, highest first; companies with the same revenue are ordered by employee count. Only companies with a positive revenue figure on file are ranked, so a large private company with no reported revenue can be missing. The list covers companies whose record places them in South Carolina and whose Factur industry is Healthcare & Life Science. Figures are a snapshot of the directory, refreshed when the rankings are regenerated; open a profile for its current data.