Largest Healthcare & Life Science Companies in South Dakota (2026)

Factur's directory lists 9,708 healthcare & life science companies in South Dakota. These are the 10 largest of them by annual revenue, led by Sanford Health ($8.1B), Avera Foundation ($3B) and Monument Health ($1.1B).

Size mix: of the 9,707 with a known headcount, 98.3% have 1-50 employees, 1.2% 51-200, 36 companies 201-1000, 1 company 1001-5000 and 5 companies 5001+. 10 employ more than 500 people.

The 10 largest healthcare & life science companies in South Dakota by annual revenue

#	Company	City	Employees	Annual revenue
1	Sanford Health	Sioux Falls	55,000	$8.1B
2	Avera Foundation	Sioux Falls	20,500	$3B
3	Monument Health	Rapid City	7,352	$1.1B
4	The Evangelical Lutheran Good Samaritan Society	Sioux Falls	15,000	$800M
5	Avera	Sioux Falls	22,100	$285M
6	Avera McKennan Hospital & University Center	Sioux Falls	581	$163M
7	Avera Health	Yankton	1,353	$143M
8	Edith Sanford Breast Cancer Foundation	Sioux Falls	83	$95M
9	McKennan Hospital	Garretson	283	$94M
10	Rapid City Medical Center LLP	Rapid City	487	$88M

How this list is ranked

Companies are ranked by annual revenue (USD) as recorded on each company's profile in the Factur directory, highest first; companies with the same revenue are ordered by employee count. Only companies with a positive revenue figure on file are ranked, so a large private company with no reported revenue can be missing. The list covers companies whose record places them in South Dakota and whose Factur industry is Healthcare & Life Science. Figures are a snapshot of the directory, refreshed when the rankings are regenerated; open a profile for its current data.